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货号: PL1403
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: PTEN
应用: WB,IHC,IF,ELISA
反应性 : Human,Mouse,Rat,
宿主物种 : Rabbit
MW(CalcμLated) : 47kD
MW(Observed): 56kD
同种型-Isotype : IgG,Kappa
偶联-Conjugate : Unmodified
隐藏域元素占位
详细信息
推荐稀释比 : IHC 1:200-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : PT0226R
抗原&靶点信息
特异性 : Endogenous
基因名称 : PTEN MMAC1 TEP1
蛋白名称 : Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
背景:
phosphatase and tensin homolog(PTEN) Homo sapiens This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate ener


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