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货号: TPFL0348
货期: 现货
价格: 1280;2180;2800
所属分类:
靶点: TP53
应用: WB, IHC-P, IF/ICC
反应性 : human
宿主物种 : Mouse
MW(CalcμLated) : 44 kDa
同种型-Isotype : IgG2a
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : Western blot (WB): 1:500-2000; Immunohistochemistry (IHC): 1:50-400; Immunocytochemistry/Immunofluorescence (ICC/IF): 1:50-400
组成 : 200ug/ml antibody with PBS ,0.02% NaN3 , 1mg BSA and 50% glycerol.
纯化工艺 : Ascites
储存 : 12 months from date of receipt,-20℃ as supplied.
浓度 : 200ug/ml
克隆性 : Monoclonal
抗原&靶点信息
基因名称 : TP53
蛋白名称 : Cellular tumor antigen p53
别名 : Antigen NY CO 13; Cellular tumor antigen p53; LFS1; P53; Phosphoprotein p53; TP53; TRP53; tumor protein p53; Tumor suppressor p53
背景:
The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.


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