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货号: TPFL0344
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: ATG5
应用: WB, IHC, ELISA
反应性 : human, mouse, rat
宿主物种 : Mouse
MW(CalcμLated) : 32 kDa
MW(Observed): 50-55 and 40-45 kDa
同种型-Isotype : IgG2a
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Protein A purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 1500 ug/ml
克隆性 : Monoclonal
抗原&靶点信息
基因名称 : ATG5
蛋白名称 : ATG5 autophagy related 5 homolog (S. cerevisiae)
别名 : 2D3B8, APG5, APG5 LIKE, APG5L, APG5-like
背景:
ATG5, also named as APG5L and ASP, belongs to the ATG5 family. It is required for autophagy. It plays an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. Formation of the autophagosome involves a ubiquitin-like conjugation system in which ATG12 is covalently bound to ATG5 and targeted to autophagosome vesicles. It mediates autophagosome-independent host protection. 66744-1-Ig antibody can recognize the ATG5-ATG12 complex (50-55 kDa) which can be truncated and generate a 40-45 kDa band. (PMID: 19783656, 25032862)


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