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货号: TPFL0342
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: BAX
应用: WB, IHC, IHC-Autostainer, IF/ICC, IP, ELISA
反应性 : human, mouse, rat
宿主物种 : Mouse
MW(CalcμLated) : 21 kDa
MW(Observed): 21 kDa
同种型-Isotype : IgG2b
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Protein A purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 1000 ug/ml
克隆性 : Monoclonal
抗原&靶点信息
基因名称 : BAX
蛋白名称 : BCL2-associated X protein
别名 : 4G5E8, Apoptosis regulator BAX, Bcl2-L-4, Bcl-2-like protein 4
背景:
BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction (PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria (PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis (PMID: 8183579).


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