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货号: TPFL0336
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: Caspase 3
应用: WB, IHC, IF/ICC, IF-P, IF-Fro, FC , IP, ELISA
反应性 : human, mouse, rat
宿主物种 : Mouse
MW(CalcμLated) : 32 kDa
MW(Observed): 17 kDa, 19 kDa
同种型-Isotype : IgG1
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Protein G purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 1000 ug/ml
克隆性 : Monoclonal
抗原&靶点信息
基因名称 : Caspase 3
蛋白名称 : caspase 3, apoptosis-related cysteine peptidase
别名 : CASP3, Caspase3, 2F7B8, CASP 3, CASP-3
背景:
Caspases, a family of endoproteases, are critical players in cell regulatory networks controlling inflammation and cell death. Initiator caspases (caspase-2, -8, -9, -10, -11, and -12) cleave and activate downstream effector caspases (caspase-3, -6, and -7), which in turn execute apoptosis by cleaving targeted cellular proteins. Caspase 3 plays a key role in the activation of sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase 3 can form heterocomplex with other proteins. This antibody is specific for cleaved caspase 3, and does not recognize full length caspase-3. The cleaved P17 and P19 fragment might form complex and shows at around 30-35 kDa by western blot (PMID: 25501826).


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