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货号: TPFL0331
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: GSDMD
应用: WB, IF/ICC, IP, ELISA
反应性 : human
宿主物种 : Mouse
MW(CalcμLated) : 484 aa, 53 kDa
MW(Observed): 47-53 kDa
同种型-Isotype : IgG2a
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Protein A purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 1000 ug/ml
克隆性 : Monoclonal
抗原&靶点信息
基因名称 : GSDMD
蛋白名称 : gasdermin D
别名 : 2E6C7, FKSG10, gasdermin D, Gasdermin domain-containing protein 1, gasderminD
背景:
GSDMD is a 53 kDa cytosolic protein and a member of the gasdermin protein family, which features 6 members in humans (GSDMA, -B, -C, -D, -E and -F. GSDMD was identified as the executioner of inflammasome-associated pyroptosis. Caspase-1, -11, or -4 cleave GSDMD after an aspartate residue within a central linker domain (D275 in humans and D276 in mice) to generate a 31-kDa N-terminal GSDMD fragment (GSDMD-NT) and a 22-kDa C-terminal fragment (GSDMD-CT). In addition to the canonical 31/22 kDa cleavage products, a 43 kDa fragment has been observed under specific experimental or pathological conditions. The generation of the 43 kDa fragment was observed upon caspase-3 and -7 activation during apoptosis. This antibody can only detect full-length GSDMD.


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