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货号: TPFL0329
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: Histone H2A.X
应用: WB, IHC, IF/ICC, FC , ELISA
反应性 : human, mouse, rat
宿主物种 : Mouse
MW(CalcμLated) : 15 kDa
MW(Observed): 17 kDa
同种型-Isotype : IgG1
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Protein G purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 1000 ug/ml
克隆性 : Monoclonal
抗原&靶点信息
基因名称 : Histone H2A.X
蛋白名称 : H2A histone family, member X
别名 : H2AFX, 3E11B2, H2A histone family, member X, H2A.X, H2AX
背景:
Histone H2A.X belongs to the histone H2A family, which is synthesized in G1 and S phases. It is involved in nucleosomal organization of chromatin together with other histone proteins and is especially important for recombination between immunoglobulin switch regions. H2A.X becomes phosphorylated on serine 139 (to form gamma-H2AFX or H2AX139ph) in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks, which promotes DNA repair and maintains genomic stability. The calculated molecular weight of H2AX is 15 kDa, but the ubiquitinated H2A.X is about 22 kDa.


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