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货号: TPFL0278
货期: 现货
价格: 1650;950
所属分类:
靶点: NLRP3
应用: WB | IHC/IF
反应性 : H,M,R | H,M,R
宿主物种 : Rabbit
MW(CalcμLated) : 118 kDa
MW(Observed): 110-118 kDa
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-1:1000; IHC/IF 1:200-1:400
组成 : PBS containing 0.15% ProClin 300, 100 μg/mL BSA and 50% glycerol.
纯化工艺 : Affinity Purification
储存 : Form: Liquid,Shipping condition: Blue Ice,Short-term storage (1–2 weeks): +4°C,Long-term storage: -20°C,Aliquot information:,Aliquot upon delivery,Storage note: Avoid freeze-thaw cycles.
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : NLRP3
蛋白名称 : NACHT, LRR and PYD domains-containing protein 3
别名 : NLRP3, AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCAS1, FCU, MWS, NALP3, PYPAF1, NLR family, pyrin domain containing 3, NLR family pyrin domain containing 3
背景:
NALP3 is a component of the innate immune system that functions as a pathogen recognition receptor (PRR) that recognizes pathogen-associated molecular patterns (PAMPs). NALP3 together with the adaptor ASC protein PYCARD forms a caspase-1 activating complex known as the NALP3 inflammasome. NALP3 in the absence of activating signal is kept in an inactive state complexed with HSP90 and SGT1 in the cytoplasm. NALP3 inflammasome detects danger signals such as crystallineuric acid and extracellular ATP released by damaged cells. These signals release of HSP90 and SGT1 from and recruit ASC protein and caspase-1 to the inflammasome complex. | |


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