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Anti -p21 Rabbit pAb

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说明书下载
货号: TPFL0276
货期: 现货
价格: 1650;950
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靶点: p21
应用: IHC/IF | ICC/IF
反应性 : H,M,R | H,M
宿主物种 : Rabbit
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : IHC/IF 1:200-1:800; ICC/IF 1:50-1:200
组成 : PBS containing 0.15% ProClin 300, 100 μg/mL BSA and 50% glycerol.
纯化工艺 : Affinity Purification
储存 : Form: Liquid,Shipping condition: Blue Ice,Short-term storage (1–2 weeks): +4°C,Long-term storage: -20°C,Aliquot information:,Aliquot upon delivery,Storage note: Avoid freeze-thaw cycles.
克隆性 : Polyclonal

抗原&靶点信息

基因名称 : CDKN1A
蛋白名称 : Cyclin-dependent kinase inhibitor 1
别名 : CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, p21, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A

数据库链接:

Organism

基因 ID

SwissProt

Mus musculus
背景:

May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding. | |

细胞定位 : Nucleus, cytoplasm

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