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货号: TPFL0260
货期: 现货
价格: 1280;2180;2800
所属分类:
靶点: HIF1A
应用: WB, IHC-P
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 93 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : Western blot (WB): 1:500-2000; Immunohistochemistry (IHC): 1:50-400
组成 : 500 ug/ml antibody with PBS, 0.02% NaN3, 1 mg/ml BSA and 50% glycerol.
纯化工艺 : Immunogen affinity purified.
储存 : 12 months from date of receipt,-20℃ as supplied.
浓度 : 500 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : HIF1A
蛋白名称 : Hypoxia-inducible factor 1-alpha
别名 : ARNT interacting protein; bHLHe78; HIF 1 alpha; HIF 1alpha; HIF1; HIF-1; HIF1 ALPHA; HIF1A; HIF-1α; Member of PAS protein 1; MOP1; PASD8
背景:
HIF-1α (Hypoxia-inducible factor 1α, HIF1A) is a transcription factor that mediates cellular and systemic homeostatic responses to reduced O2 availability in mammals, including angiogenesis, erythropoiesis and glycolysis. This gene was mapped to 14q21-q24. HIF-1α transactivate genes required for energy metabolism and tissue perfusion and is necessary for embryonic development and tumor explant growth. HIF-1alpha is over expressed during carcinogenesis, myocardial infarction and wound healing. It is crucial for the cellular response to hypoxia and is frequently over expressed in human cancers, resulting in the activation of genes essential for cell survival. HIF-1α regulates the survival and function in the inflammatory microenvironment directly. It is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability.


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