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货号: TPFL0255
货期: 现货
价格: 1280;2180;2800
所属分类:
靶点: MFN1
应用: WB
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 84 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : Western blot (WB): 1:500-2000
组成 : 500 ug/ml antibody with PBS, 0.02% NaN3, 1 mg/ml BSA and 50% glycerol.
纯化工艺 : Immunogen affinity purified.
储存 : 12 months from date of receipt,-20℃ as supplied.
浓度 : 500 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : MFN1
蛋白名称 : Mitofusin-1
别名 : Fzo homolog; hfzo1; hfzo2; MFN1; mitofusin 1; Transmembrane GTPase MFN1
背景:
Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene. It is an 80?90 kDa mitochondrial member of the dynamin family of molecules. It is ubiquitously expressed, and found in the outer mitochondrial membrane. The protein encoded by this gene is a mediator of mitochondrial fusion, and thereby contribute to the dynamic balance between fusion and fission that determines mitochondria morphology. MFN1 is known to form oligomers, either with itself or MFN?2, and to undergo ubiquitination by MARCH5. MFN?1 has two key domains. One is a coiled?coil region that mediates MFN?1: MFN?1/2 binding, and a second is a GTPase domain whose cleavage of GTP is necessary for membrane fusion. Overexpression of MFN1 caused perinuclear mitochondrial clustering.


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