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货号: TPFL0244
货期: 现货
价格: 1280;2180;2800
所属分类：
靶点: PGK1
应用： WB, IF/ICC, FCM
反应性 ： human, mouse, rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 45 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 ： Western blot (WB): 1:500-2000; Immunocytochemistry/Immunofluorescence (ICC/IF): 1:50-400; Flow Cytometry (Fixed): 1:50-200
组成 ： 500 ug/ml antibody with PBS, 0.02% NaN3, 1 mg/ml BSA and 50% glycerol.
纯化工艺 ： Immunogen affinity purified.
储存 ： 12 months from date of receipt，-20℃ as supplied.
浓度 ： 500 ug/ml
克隆性 ： Polyclonal
抗原&靶点信息
基因名称 ： PGK1
蛋白名称 ： Phosphoglycerate kinase 1
别名 ： MIG10; OK/SW cl.110; PGK1; PGKA; phosphoglycerate kinase 1; Primer recognition protein 2; PRP 2
背景：
PGK1 (Phosphoglycerate Kinase 1), also known as PGKA, is an enzyme that in humans is encoded by the PGK1 gene. The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome.
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