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货号: TPFL0201
货期: 现货
价格: 1350;2200;3000
所属分类：
靶点: E-cadherin
应用： WB, IHC, IF/ICC, IF-P, IF-Fro, FC , IP, ELISA
反应性 ： human, mouse, rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 882 aa, 97 kDa
MW(Observed)： 120-125 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
组成 ： PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 ： Antigen affinity purification
储存 ： Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 ： 650 ug/ml
克隆性 ： Polyclonal
抗原&靶点信息
基因名称 ： E-cadherin
蛋白名称 ： cadherin 1, type 1, E-cadherin (epithelial)
别名 ： Arc 1, Cadherin 1, Cadherin-1, CAM 120/80, CD324
背景：
Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also includes N-, P-, R-, and B-cadherins. E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of epithelial integrity and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cells. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein, and its loss is an indicator of high tumor aggressiveness. E-cadherin is sensitive to trypsin digestion in the absence of Ca2+. This polyclonal antibody recognizes 120-125 kDa intact E-cadherin and its cleaved fragments of 80-120 kDa.
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