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Granzyme B Polyclonal antibody

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说明书下载
货号: TPFL0189
货期: 现货
价格: 1350;2200;3000
+

所属分类:


靶点: Granzyme B
应用: WB, IHC, IF/ICC, IF-P, IF-Fro, ELISA
反应性 : human, mouse
宿主物种 : Rabbit
MW(CalcμLated) : 247 aa, 28 kDa
MW(Observed): 33 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated

隐藏域元素占位

详细信息

组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 390 ug/ml
克隆性 : Polyclonal

抗原&靶点信息

基因名称 : Granzyme B
蛋白名称 : granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
别名 : GZMB, Cathepsin G-like 1, CCPI, CGL 1, CGL1

数据库链接:

Organism

基因 ID

SwissProt

背景:

GZMB(Granzyme B) is also named as CGL1, CSPB, CTLA1, GRB and belongs to the Granzyme subfamily. This enzyme is necessary for target cell lysis in cell-mediated immune responses. The cytotoxic lymphocyte protease granzyme B (GzmB) can promote apoptosis through direct processing and activation of members of the caspase family. GzmB can also cleave the BH3-only protein, BID, to promote caspase-independent mitochondrial permeabilization (PMID:17283187). GzmB induces laminB degradation in isolated nuclei less efficiently than GzmA (PMID:11331782). This full length protein has 2 glycosylation sites and a signal peptide. Unglycosylated human granzyme B is 26 kDa and high mannose glycosylated is 32 kDa and only 32kDa or smaller forms of granzyme B are accumulated within nuclei (PMID:8626751). GzmB also forms dimers.

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