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IKBKB Polyclonal antibody

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说明书下载
货号: TPFL0176
货期: 现货
价格: 1350;2200;3000
+

所属分类:


靶点: IKBKB
应用: WB, IHC, IP, ELISA
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 756aa,81 kDa; 256aa,29 kDa
MW(Observed): 80 kDa, 86 kDa, 87 and 29 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated

隐藏域元素占位

详细信息

组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 790 ug/ml
克隆性 : Polyclonal

抗原&靶点信息

基因名称 : IKBKB
蛋白名称 : inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
别名 : IKBKB, EC:2.7.11.1, EC:2.7.11.10, I kappa B kinase 2, I kappa B kinase beta

数据库链接:

Organism

基因 ID

SwissProt

背景:

IKBKB, also named as IKKB, IKK2, NFKBIKB and IKK-B, belongs to the protein kinase superfamily, Ser/Thr protein kinase family and I-kappa-B kinase subfamily. IKBKB is a Serine kinase that plays an essential role in the NF-kappa-B signaling pathway. It acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. In addition to the NF-kappa-B inhibitors, IKBKB phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. It also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, IKBKB acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. This antibody can identify 4 isoform of IKBKB with the molecular weight of 80, 86, 87 and 29 kDa.

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