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货号: TPFL0173
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: iNOS
应用: WB, IHC, FC , ELISA
反应性 : human, mouse
宿主物种 : Rabbit
MW(CalcμLated) : 1153 aa, 131 kDa
MW(Observed): 110-130 kDa, 65-70 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 750 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : iNOS
蛋白名称 : nitric oxide synthase 2, inducible
别名 : NOS2, EC:1.14.13.39, Hepatocyte NOS, HEP-NOS, Inducible NO synthase
背景:
NOS2, also named as iNOS and NOS2A, produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. NO is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission, antimicrobial and antitumoral activities. NOS2 is a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. iNOS has a very short half-life due to rapid degradation by calpain. iNOS monomer is a direct substrate of calpain I and can be cleaved by calpain I at the canonical CaM-binding site(503-532aa) of iNOS, and then a ~70kD band can be detected by western (PMID:11786228).


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