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货号: TPFL0161
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: NCAM1
应用: WB, IHC, IF/ICC, IF-P, ELISA
反应性 : human, mouse, rat, pig
宿主物种 : Rabbit
MW(CalcμLated) : 95 kDa
MW(Observed): 120 kDa, 140 kDa, 180 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 850 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : NCAM1
蛋白名称 : neural cell adhesion molecule 1
别名 : CD56, NCAM1, MSK39, N CAM 1, NCAM
背景:
Neural cell adhesion molecule 1 (NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin (Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurons, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety of human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA (PMID: 9696812). The glycosylphosphatidylinositol (GPI)-anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronection-type III repeats (FNIII). All three forms can be posttranslationally modified by addition of polysialic acid (PSA) (PMID: 14976519). Several other isofroms have also been described (PMID: 1856291).


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