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货号: TPFL0155
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: NRF2
应用: WB, IHC, IF/ICC, ELISA
反应性 : human
宿主物种 : Rabbit
MW(CalcμLated) : 605 aa, 68 kDa
MW(Observed): 95-110 kDa, 68 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 800 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : NRF2
蛋白名称 : nuclear factor (erythroid-derived 2)-like 2
别名 : NRF2, NFE2L2, NFE2L2, NRF2, HEBP1, NF-E2-related factor 2
背景:
NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress (PMID:14567983).In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance(PMID:20534738). Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC.


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