信号通路

联系我们

15392937510

地址:湖北省武汉市江夏区神墩四路 666 号武汉国英种业大厦A栋14F 
邮箱:pinuofei2017@163.com
TEL:15392937510

PIN1 Polyclonal antibody

复制产品信息

说明书下载
货号: TPFL0144
货期: 现货
价格: 1350;2200;3000
+

所属分类:


靶点: PIN1
应用: WB, IHC, IF/ICC, IP, ELISA
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 18 kDa
MW(Observed): 18 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated

隐藏域元素占位

详细信息

组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 600 ug/ml
克隆性 : Polyclonal

抗原&靶点信息

基因名称 : PIN1
蛋白名称 : peptidylprolyl cis/trans isomerase, NIMA-interacting 1
别名 : Pin 1, Peptidyl-prolyl cis-trans isomerase Pin1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, EC:5.2.1.8

数据库链接:

Organism

基因 ID

SwissProt

背景:

PIN1(Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) is essential for mitosis progression in yeast cells and is hypothesized to perform the same role in mammalian cells. It might regulate cellular processes distinct from the cell cycle itself, such as terminal differentiation through a modulation of differentiation-specific gene expression(PMID:20801874). It colocalizes with NEK6 in the nucleus. Pin1 inhibition simultaneously blocks multiple cancer pathways, disrupts the desmoplastic and immunosuppressive TME, and upregulates PD-L1 and ENT1, rendering pancreatic ductal adenocarcinoma (PDAC) eradicable by immunochemotherapy (PMID: 34388391).

推荐产品

相关文献

留言咨询

留下您想咨询的信息,我们会尽快联系您

提交