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货号: TPFL0134
货期: 现货
价格: 1180.00;1980.00;2800.00
所属分类:
靶点: Caspase-1 P10
应用: IHC-P, IHC-F, IF, Flow-Cyt
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 10/45 kDa
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : IHC-P 1:100-500; IHC-F 1:100-500; IF 1:100-500; Flow-Cyt 1ug/Test
组成 : 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
纯化工艺 : affinity purified by Protein A
储存 : Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
浓度 : 1mg/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : CASP1
蛋白名称 : Caspase-1
别名 : ICE; IL1BC; P45; CASP1_HUMAN; CASP1; CASP-1; Interleukin-1 beta convertase (IL-1BC); Interleukin-1 beta-converting enzyme (ICE | IL-1 beta-converting enzyme); 3.4.22.36; IL1BCE; CASP1_MOUSE; CASP1_RAT; caspase 1; caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase); caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase 1, apoptosis-related cysteine peptidase; caspase-1; interleukin 1, beta, convertase
背景:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq].


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