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货号: TPFL0131
货期: 现货
价格: 1180.00;1980.00;2800.00
所属分类：
靶点: PPAR alpha
应用： WB, IHC-P, IHC-F, IF, Flow-Cyt
反应性 ： Human,Mouse
宿主物种 ： Rabbit
MW(CalcμLated) ： 51 kDa
MW(Observed)： 51 kDa
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:500-2000; IHC-P 1:100-500; IHC-F 1:100-500; IF 1:100-500; Flow-Cyt 1ug/Test
组成 ： 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
纯化工艺 ： affinity purified by Protein A
储存 ： Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
浓度 ： 1mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
基因名称 ： PPARA
蛋白名称 ： Peroxisome proliferator-activated receptor alpha
别名 ： NR1C1; PPAR; PPAR-alpha; PPARalpha; hPPAR; 4933429D07Rik; PPARA_HUMAN; PPARA; Nuclear receptor subfamily 1 group C member 1; Q6I9S0_HUMAN; PPARA_MOUSE; Q542P9_MOUSE; PPARA_RAT; peroxisome proliferator activated receptor alpha; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated receptor alpha
背景：
Peroxisome proliferators are nongenotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed Peroxisome Proliferator Activated Receptors (PPARs). Nuclear hormone receptors are ligand dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 A6 (CYP450 A6) through interaction with specific response elements. PPAR alpha is activated by free fatty acids including linoleic, arachidonic, and oleic acids. Induction of peroxisomes by this mechanism leads to a reduction in blood triglyceride levels. PPAR alpha is expressed mainly in skeletal muscle, heart, liver, and kidney and is thought to regulate many genes involved in the beta-oxidation of fatty acids. Activation of rat liver PPAR alpha has been shown to suppress hepatocyte apoptosis. PPAR alpha, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex.
细胞定位 ： Nucleus.
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