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货号: TPFL0130
货期: 现货
价格: 1180.00;1980.00;2800.00
所属分类：
靶点: TNF alpha
应用： Flow-Cyt, ICC/IF
反应性 ： Human,Mouse
宿主物种 ： Rabbit
MW(CalcμLated) ： 17/26 kDa
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： Flow-Cyt 1ug/Test; ICC/IF 1:100-500
组成 ： 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
纯化工艺 ： affinity purified by Protein A
储存 ： Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
浓度 ： 1mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
基因名称 ： TNF
蛋白名称 ： Tumor necrosis factor
别名 ： DIF; IMD127; TNF-alpha; TNFA; TNFSF2; TNLG1F; TNF-a; TNFalpha; Tnfsf1a; TNFA_HUMAN; TNF; Cachectin; Tumor necrosis factor ligand superfamily member 2 (TNF-a); TNFA_MOUSE; TNFA_CANLF; TNFA_RAT; RATTNF; tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); TNF superfamily, member 2
背景：
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020]
细胞定位 ： Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted.
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