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货号: TPFL0126
货期: 现货
价格: 1180.00;1980.00;2800.00
所属分类:
靶点: IL-10
应用: WB, IHC-P, IHC-F, IF
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(CalcμLated) : 18 kDa
MW(Observed): 21 kDa
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-2000; IHC-P 1:100-500; IHC-F 1:100-500; IF 1:100-500
组成 : 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
纯化工艺 : affinity purified by Protein A
储存 : Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
浓度 : 1mg/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : IL10
蛋白名称 : Interleukin-10
别名 : CSIF; GVHDS; IL-10; IL10A; TGIF; If2a; IL10X; IL10_HUMAN; IL10; Cytokine synthesis inhibitory factor (CSIF); IL10_MOUSE; IL10_RAT; interleukin 10; cytokine synthesis inhibitory factor; T-cell growth inhibitory factor
背景:
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]


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