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货号: TPFL0124
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: RUNX2
应用: WB, IHC, IF/ICC, FC , IP, ELISA
反应性 : human, rat
宿主物种 : Rabbit
MW(CalcμLated) : 57 kDa
MW(Observed): 57-60 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 510 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : RUNX2
蛋白名称 : runt-related transcription factor 2
别名 : AML3, AML-3, CBF-alpha-1, Core-binding factor subunit alpha-1, OSF 2
背景:
RUNX2, also named as AML3, CBFA1, OSF2 and PEBP2A, is a Transcription factor which involved in osteoblastic differentiation and skeletal morphogenesis. It is essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters By similarity. RUNX2 inhibits MYST4-dependent transcriptional activation. The antibody is specific to RUNX2.


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