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货号: TPFL0115
货期: 现货
价格: 1350;2200;3000
所属分类：
靶点: STAT3
应用： WB, IHC, IF/ICC, FC , IP, ELISA
反应性 ： human, mouse
宿主物种 ： Rabbit
MW(CalcμLated) ： 770 aa, 88 kDa
MW(Observed)： 88 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
组成 ： PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 ： Antigen affinity purification
储存 ： Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 ： 260 ug/ml
克隆性 ： Polyclonal
抗原&靶点信息
基因名称 ： STAT3
蛋白名称 ： signal transducer and activator of transcription 3 (acute-phase response factor)
别名 ： Acute-phase response factor, APRF, HIES, STAT 3
背景：
Signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3, synonyms: APRF, FLJ20882, MGC16063) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human STAT3. STAT3 exists three isoforms and the molecular weight of each isoform respectively is 83 kDa, 87 kDa and 88 kDa.
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