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货号: TPFL0111
货期: 现货
价格: 1350;2200;3000
所属分类：
靶点: TNF-alpha
应用： WB, IF/ICC, ELISA
反应性 ： human, mouse
宿主物种 ： Rabbit
MW(CalcμLated) ： 233 aa, 26 kDa
MW(Observed)： 26 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
组成 ： PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 ： Antigen affinity purification
储存 ： Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 ： 600 ug/ml
克隆性 ： Polyclonal
抗原&靶点信息
基因名称 ： TNF-alpha
蛋白名称 ： tumor necrosis factor (TNF superfamily, member 2)
别名 ： TNF, TNF alpha, TNF-a, C-domain 1, C-domain 2
背景：
TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, ins resistance, and cancer.
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