信号通路

联系我们

15392937510

地址:湖北省武汉市江夏区神墩四路 666 号武汉国英种业大厦A栋14F 
邮箱:pinuofei2017@163.com
TEL:15392937510

TYROBP/DAP12 Polyclonal antibody

复制产品信息

说明书下载
货号: TPFL0108
货期: 现货
价格: 1350;2200;3000
+

所属分类:


靶点: TYROBP
应用: WB, ELISA
反应性 : human and More (1)
宿主物种 : Rabbit
MW(CalcμLated) : 12 kDa
MW(Observed): 10-12 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated

隐藏域元素占位

详细信息

组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 230 ug/ml
克隆性 : Polyclonal

抗原&靶点信息

基因名称 : TYROBP
蛋白名称 : TYRO protein tyrosine kinase binding protein
别名 : TYROBP, DAP12, DNAX activation protein 12, DNAX-activation protein 12, KAR associated protein

数据库链接:

Organism

基因 ID

SwissProt

背景:

TYROBP, also known as DAP12 or KARAP, is a transmembrane protein consisting of a very small extracellular region, a transmembrane domain containing an aspartic acid residue critical for association with its partner subunits, and an intracellular domain with a single immunoreceptor tyrosine-based activation motif (ITAM) (PMID: 11114420). It is expressed as a disulfide-bonded homodimer on natural killer cells, myeloid cells and a subset of T cells (PMID: 11114420). TYROBP acts as a signaling adaptor that provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways (PMID: 15895090). The gene of TYROBP is located on the long arm of chromosome 19 at position 13.1. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

推荐产品

相关文献

留言咨询

留下您想咨询的信息,我们会尽快联系您

提交