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货号: TPFL0108
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: TYROBP
应用: WB, ELISA
反应性 : human and More (1)
宿主物种 : Rabbit
MW(CalcμLated) : 12 kDa
MW(Observed): 10-12 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 230 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : TYROBP
蛋白名称 : TYRO protein tyrosine kinase binding protein
别名 : TYROBP, DAP12, DNAX activation protein 12, DNAX-activation protein 12, KAR associated protein
背景:
TYROBP, also known as DAP12 or KARAP, is a transmembrane protein consisting of a very small extracellular region, a transmembrane domain containing an aspartic acid residue critical for association with its partner subunits, and an intracellular domain with a single immunoreceptor tyrosine-based activation motif (ITAM) (PMID: 11114420). It is expressed as a disulfide-bonded homodimer on natural killer cells, myeloid cells and a subset of T cells (PMID: 11114420). TYROBP acts as a signaling adaptor that provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways (PMID: 15895090). The gene of TYROBP is located on the long arm of chromosome 19 at position 13.1. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.


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