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货号: TPFL0093
货期: 现货
价格: 1280;2180;2800
所属分类:
靶点: JAK2
应用: WB, IHC-P, IF/ICC
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 131 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : Western blot (WB): 1:500-2000; Immunohistochemistry (IHC): 1:50-200; Immunocytochemistry/Immunofluorescence (ICC/IF): 1:50-200; ImmunoPrecipitation (IP): 1:50-100
组成 : 500 ug/ml; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/ml BSA and 50% glycerol.
纯化工艺 : Affinity-chromatography
储存 : 12 months from date of receipt,-20℃ as supplied.
浓度 : 500 ug/ml
克隆性 : Monoclonal
抗原&靶点信息
基因名称 : JAK2
别名 : Janus kinase 2; JTK10; JAK2
背景:
Janus kinase 2, commanly called JAK2, is a human protein that has been implicated in signaling by members of the type II cytokine receptor family, the GM-CSF receptor family, the gp130 receptor family, and the single chain receptors. Exactly, JAK2 kinase is a member of a family of tyrosine kinases involved in cytokine receptor signaling. The JAK2 gene is mapped to 9p24.1. The JAK2 gene encodes a 1,132-amino acid protein that shares 95% sequence similarity to rat and pig Jak2. JAK2 is constitutively associated with the prolactin receptor and that it is activated and tyrosine phosphorylated upon PRL binding to the PRL receptor. JAK2, and more specifically just its intact N-terminal domain, binds to EPOR in the endoplasmic reticulum and promotes its cell surface expression. The human JAK2 is present in the nucleus of hematopoietic cells and directly phosphorylates tyr41 on histone H3.


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