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货号: TPFL0090
货期: 现货
价格: 1280;2180;2800
所属分类:
靶点: PRKN
应用: WB, IHC-P, IF/ICC, IP, FCM
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 52 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : Western blot (WB): 1:500-2000; Immunohistochemistry (IHC): 1:50-200; Immunocytochemistry/Immunofluorescence (ICC/IF): 1:50-200; ImmunoPrecipitation (IP): 1:20; Flow Cytometry (FCM): 1:20
组成 : 500 ug/ml; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/ml BSA and 50% glycerol.
纯化工艺 : Affinity-chromatography
储存 : 12 months from date of receipt,-20℃ as supplied.
浓度 : 500 ug/ml
克隆性 : Monoclonal
抗原&靶点信息
基因名称 : PRKN
别名 : AR JP; LPRS2; PARK2; PARK2/Parkin; Parkin; Parkinson disease protein 2; PDJ; PRKN
背景:
Parkin is a RING domain-containing E3 ubiquitin ligase involved in proteasome-dependent degradation of proteins. It is mapped to 6q26. This gene is important for mitochondrial quality control by lysosome-dependent degradation of damaged mitochondria through autophagy, or mitophagy. Parkin is expressed in neuronal processes and cell bodies of neurons, but not glial cells, in the midbrain, basal ganglia, cerebral cortex, and cerebellum. Parkin assimilated with actin filaments, suggesting that it is a cytoskeletal-associated protein. Parkin is identified as a transcriptional repressor of p53 independent of its ubiquitin ligase function. It also has been found that parkin was associated physically with mitochondrial DNA (mtDNA) in proliferating as well as in differentiated SH-SY5Y neuroblastoma cells.


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