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货号: TPFL0085
货期: 现货
价格: 790;1240;1990;3790
所属分类:
靶点: BDNF
应用: WB, IHC, IF, FCM
反应性 : Human, Mouse, Rat
宿主物种 : Rabbit
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:1000
组成 : PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN₃
储存 : –20°C (avoid freeze-thaw cycles), 2 years
克隆性 : Monoclonal
克隆号 : E17G19
抗原&靶点信息
特异性 : BDNF Antibody (Rabbit mAb) [E17G19]
基因名称 : BDNF
蛋白名称 : Neurotrophic factor BDNF precursor form
别名 : Abrineurin | ANON2 | BDNF | BDNF precursor form | brain derived neurotrophic factor | Brain-derived neurotrophic factor | BULN2 | MGC34632 | neurotrophin | ProBDNF
背景:
Brain-derived Neurotrophic Factor (BDNF) is a key neurotrophic factor involved in the development, survival, and function of neurons, affecting synaptic plasticity and efficiency in the central nervous system. Structurally, the BDNF gene on chromosome 11 consists of 11 exons and multiple promoters, with exon IV regulating activity-dependent expression. BDNF is synthesized as pre-pro-BDNF in the endoplasmic reticulum, which is processed into pro-BDNF and then into mature BDNF. BDNF binds to the TrkB receptor, activating downstream signaling pathways such as MAPK, PLC-γ, and PI3K, which are crucial for neural plasticity and synaptic development.


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