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货号: TPFL0082
货期: 现货
价格: 790;1240;1990;3790
所属分类：
靶点: Macrophage mannose receptor 1
应用： WB, IP, IHC, IF
反应性 ： Human, Mouse, Rat, Monkey
宿主物种 ： Rabbit
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000
组成 ： PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
储存 ： -20°C (avoid freeze-thaw cycles), 2 years
克隆性 ： Monoclonal
克隆号 ： K13P18
抗原&靶点信息
特异性 ： CD206/MRC1 Antibody (Rabbit mAb) [K13P18]
基因名称 ： MRC1
蛋白名称 ： Macrophage mannose receptor 1
别名 ： Macrophage mannose receptor 1, MMR, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Human mannose receptor (hMR), Macrophage mannose receptor 1-like protein 1, CD206, MRC1, CLEC13D, CLEC13DL, MRC1L1
背景：
CD206, also known as the mannose receptor or MRC1, is a type I transmembrane C-type lectin receptor primarily expressed on macrophages, immature dendritic cells, and certain endothelial cells, playing a crucial role in immune surveillance and homeostasis. CD206 contains an N-terminal cysteine-rich domain, a type II fibronectin domain, and eight C-type lectin carbohydrate recognition domains (CRDs), which mediate high-affinity binding to glycans containing terminal mannose, fucose, and N-acetylglucosamine residues. CD206 recognizes and internalizes various endogenous glycoproteins and pathogenic microorganisms through clathrin-mediated endocytosis, promoting antigen uptake, glycoprotein clearance, and regulation of immune responses, including facilitating anti-inflammatory signaling and tissue repair. The expression and activity of CD206 are closely associated with macrophage polarization, being upregulated in (M2) macrophages activated by cytokines such as IL-4 and IL-13, while downregulated under pro-inflammatory conditions. Furthermore, post-translational modifications such as glycosylation affect receptor stability and trafficking, while pH-dependent conformational changes in the endosomal compartment promote ligand release and receptor recycling. CD206 is dynamically regulated and serves as an important mediator of immune homeostasis, pathogen recognition, and inflammation resolution.
细胞定位 ： Cell membrane, endosome, endomembrane system
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