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货号: TPFL0081
货期: 现货
价格: 790;1240;1990;3790
所属分类:
靶点: CD3E
应用: WB, IHC, FCM
反应性 : Human, Mouse, Rat
宿主物种 : Rabbit
MW(CalcμLated) : 23 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:1000
组成 : PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN₃
储存 : -20°C (avoid freeze-thaw cycles), 2 years
克隆性 : Monoclonal
克隆号 : G22E13
抗原&靶点信息
特异性 : CD3 epsilon Antibody (Rabbit mAb) [G22E13]
基因名称 : CD3E
蛋白名称 : T-cell surface glycoprotein CD3 epsilon chain
别名 : CD3e | T3E | CD3E | T-cell surface glycoprotein CD3 epsilon chain | T-cell surface antigen T3/Leu-4 epsilon chain
背景:
CD3ε is a type I transmembrane protein encoded by the CD3E gene on chromosome 11, which is essential for T cell receptor (TCR) signaling and immune responses. Structurally, it has an extracellular domain for TCR interaction, a transmembrane segment, and a cytoplasmic tail containing immunoreceptor tyrosine-based activation motifs (ITAMs), which are critical for initiating signal cascades. CD3ε forms heterodimers with CD3γ, CD3δ, and CD3ζ, assembling the TCR-CD3 complex necessary for T cell activation. It is mainly expressed in mature T cells (CD4+ and CD8+) and thymocytes, playing a key role in T cell activation, proliferation, differentiation, and thymocyte maturation. CD3ε is also an integral part of CAR-T cell function and immunotherapy.


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