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货号: TPFL0080
货期: 现货
价格: 790;1240;1990;3790
所属分类:
靶点: CD31
应用: WB, IHC
反应性 : Mouse
宿主物种 : Rabbit
MW(CalcμLated) : 135 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:1000
组成 : PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN₃
储存 : –20°C (avoid freeze-thaw cycles), 2 years
克隆性 : Monoclonal
克隆号 : M18G16
抗原&靶点信息
特异性 : CD31 (PECAM-1) Antibody (Rabbit mAb) [M18G16]
基因名称 : PECAM1
蛋白名称 : Platelet endothelial cell adhesion molecule
别名 : adhesion molecule | CD31 | CD31 antigen | CD31/EndoCAM | EndoCAM | FLJ58394 | GPIIA' | PECA1 | PECAM-1 | PECAM-1 | CD31/EndoCAM | PECAM1 | platelet and endothelial cell adhesion molecule 1 | Platelet endothelial cell adhesion molecule | platelet endothelial cell adhesion molecule-1 | platelet/endothelial cell adhesion molecule
背景:
Platelet/endothelial cell adhesion molecule-1 (PECAM-1), also known as CD31, is an important cell adhesion and signaling molecule primarily present in endothelial cells, circulating platelets, monocytes, neutrophils, and some T cells. PECAM-1 is enriched at endothelial junctions, where it plays a crucial role in maintaining vascular integrity by promoting homophilic interactions that support vascular permeability and leukocyte migration. The cytoplasmic domain of CD31 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which, upon phosphorylation by Src family kinases (particularly at Tyr686), recruit various signaling adaptor molecules such as SHP-2, PI3 kinase, and PLC gamma. This phosphorylation regulates signaling pathways that enhance endothelial cell motility and survival. It also positions CD31 as a central scaffold integrating multiple signaling pathways involved in cell adhesion, migration, and angiogenesis.


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