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CD86 (E5W6H) Rabbit mAb

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货号: TPFL0078
货期: 现货
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所属分类:


靶点: CD86
应用: W, IHC-Bond, IHC-P
反应性 : M
宿主物种 : Rabbit
MW(Observed): 60-85
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : Application Dilution Western Blotting 1:1000 IHC Leica Bond 1:200 - 1:800 Immunohistochemistry (Paraffin) 1:100 - 1:400
来源 : Rabbit
纯化工艺 : Monoclonal antibody is produced by immunizing animals with mouse CD86 recombinant protein.
储存 : Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody . For a carrier free (BSA and azide free) version of this product see product # 20018 .
克隆性 : Monoclonal
克隆号 : E5W6H

抗原&靶点信息

特异性 : CD86 (E5W6H) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD86 protein.

数据库链接:

Organism

基因 ID

SwissProt

背景:

CD80 (B7-1, BB1) and CD86 (B7-2, B70) are members of the B7 family of cell surface ligands that regulate T cell activation and immune responses. CD80 is expressed on activated antigen presenting cells, including dendritic cells, B cells, monocytes, and macrophages. CD86 is expressed on resting monocytes, dendritic cells, activated B lymphocytes, and can be further upregulated in the presence of inflammation (1-3). CD80 and CD86 are ligands for CD28, which functions as a T cell costimulatory receptor. Interaction of CD28 with CD80 or CD86 provides the second signal required for naïve T cell activation, T cell proliferation, and acquisition of effector functions (3-7). Alternatively, CD80 and CD86 also act as ligands to CTLA-4, which results in the downregulation of T cell activity (3,7-9).

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