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货号: TPFL0071
货期: 现货
价格: 790;1240;1990;3790
所属分类:
靶点: Cytokeratin 7
应用: WB, IHC, IF, FCM
反应性 : Mouse, Rat, Human
宿主物种 : Rabbit
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:1000
组成 : PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN₃
储存 : –20°C (avoid freeze-thaw cycles), 2 years
克隆性 : Monoclonal
克隆号 : F14P23
抗原&靶点信息
特异性 : Cytokeratin 7 Antibody (Rabbit mAb) [F14P23]
基因名称 : KRT7
蛋白名称 : Keratin, type II cytoskeletal 7
别名 : CK-7 | CK7 | cytokeratin 7 | Cytokeratin-7 | K2C7 | K7 | keratin 7 | keratin 7 | type II | Keratin-7 | keratin | 55K type II cytoskeletal | keratin | simple epithelial type I | K7 | Keratin | type II cytoskeletal 7 | KRT7 | MGC129731 | MGC3625 | Sarcolectin | SCL | type II mesothelial keratin K7 | Type-II keratin Kb7
背景:
Cytokeratins (CK or keratins) are a group of intermediate filament proteins found in epithelial cells. According to conventional classification, they are divided into type I (CK9-20) and type II (CK1-8) proteins. These proteins play a crucial role in maintaining the structural integrity of epithelial cells and also regulate various cellular processes, including growth, proliferation, migration, apoptosis, and immunity. CK7 is an intermediate filament protein with a molecular weight of 54 kDa, detected by immunohistochemical staining and positively expressed in the cell cytoplasm. It is widely expressed in many normal epithelial tissues such as breast and lung tissues, and its expression pattern can help distinguish benign from malignant epithelial tumors. In addition, CK7 serves as a specific marker for biliary epithelial cells, aiding in the diagnosis of cancers such as intrahepatic cholangiocarcinoma and hepatocellular carcinoma.


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