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货号: TPFL0066
货期: 现货
所属分类：
靶点: FOXP3FoxP3
应用： IHC-Bond, IHC-P, IF-F, FC-FP
反应性 ： M Mk
宿主物种 ： Rabbit
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： Application Dilution IHC Leica Bond 1:800 - 1:3200 Immunohistochemistry (Paraffin) 1:200 - 1:800 Immunofluorescence (Frozen) 1:400 - 1:800 Flow Cytometry (Fixed/Permeabilized) 1:50 - 1:200
来源 ： Rabbit
纯化工艺 ： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro44 of mouse FoxP3 protein.
储存 ： Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 72338 .
克隆性 ： Monoclonal
克隆号 ： D6O8R
抗原&靶点信息
特异性 ： FoxP3 (D6O8R) Rabbit Monoclonal Antibody recognizes endogenous levels of total FoxP3 protein.
背景：
Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors containing a sequence known as Forkhead box or winged helix DNA binding domain (1). The human genome contains 43 Fox proteins that are divided into subfamilies. The FoxP subfamily has four members, FoxP1 - FoxP4, which are broadly expressed and play important roles in organ development, immune response, and cancer pathogenesis (2-4). The FoxP subfamily has several characteristics that are atypical among Fox proteins: their Forkhead domain is located at the carboxy-terminal region and they contain motifs that promote homo- and heterodimerization. FoxP proteins usually function as transcriptional repressors (4,5). FoxP3 is crucial for the development of T cells with regulatory properties (Treg) (6). Mutations in FoxP3 are associated with immune dysregulation, polyendocrinopathy, enteropathy, and X-linked syndrome (IPEX) (7), while overexpression in mice causes severe immunodeficiency (8). Research studies have shown that FoxP3 functions as a tumor suppressor in several types of cancer (9-11).
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