产品服务
信号通路
货号: TPFL0064
货期: 现货
价格: 790;1240;1990;3790
所属分类:
靶点: Ki-67
应用: WB, IHC, IF, FCM
反应性 : Human, Mouse, Rat
宿主物种 : Rabbit
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:100 - 1:500
组成 : PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
储存 : -20°C (avoid freeze-thaw cycles), 2 years
克隆性 : Monoclonal
克隆号 : J16J15
抗原&靶点信息
特异性 : Ki67 Antibody (Rabbit mAb) [J16J15]
基因名称 : MKI67
蛋白名称 : Proliferation marker protein Ki-67
别名 : Proliferation marker protein Ki-67; Antigen identified by monoclonal antibody Ki-67; Antigen KI-67; Antigen Ki67; MKI67
背景:
Ki-67 is a large nuclear and nucleolar protein encoded by the MKI67 gene, widely used as a marker of cell proliferation. Its structure includes an N-terminal forkhead-associated (FHA) domain, a protein phosphatase 1 (PP1) binding region, central tandem repeats, and a C-terminal leucine/arginine-rich chromatin-binding domain, and it produces multiple isoforms through alternative splicing. Ki-67 is expressed in all active phases of the cell cycle (G1, S, G2, and M phases) but is absent in quiescent cells (G0 phase), making it a reliable proliferation indicator in cancer diagnosis. Functionally, it plays key roles in organizing interphase heterochromatin, assembling the perichromosomal layer (PCL) during mitosis to prevent chromosome aggregation, and regulating cell cycle progression through interactions with PP1 and other chromatin-associated proteins.


微信客服