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货号: TPFL0063
货期: 现货
价格: 790;1240;1990;3790
所属分类:
靶点: Lamp1
应用: WB, IP, IHC, IF, FCM
反应性 : Mouse
宿主物种 : Rabbit
MW(CalcμLated) : 90-120 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:1000
组成 : PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN₃
储存 : -20°C (avoid freeze-thaw cycles), 2 years
克隆性 : Monoclonal
克隆号 : C20P18
抗原&靶点信息
特异性 : LAMP1 Antibody (Rabbit mAb) [C20P18]
基因名称 : Lamp1
蛋白名称 : Lysosome-associated membrane glycoprotein 1
别名 : CD107a | Lamp-1 | Lamp1 | Lysosome-associated membrane glycoprotein 1 | LAMP-1 | Lysosome-associated membrane protein 1 | 120 kDa lysosomal membrane glycoprotein | CD107 antigen-like family member A | LGP-120 | Lysosomal membrane glycoprotein A | P2B | LGP-A
背景:
LAMP-1 (lysosomal-associated membrane protein 1) is an indispensable glycoprotein in the lysosomal membrane of eukaryotic cells, playing a crucial role in maintaining lysosomal integrity and function. Structurally, it is a type I transmembrane protein characterized by a large luminal domain with extensive glycosylation, forming a protective glycocalyx that shields the lysosomal membrane from degradation by acidic hydrolases. This glycosylation protects the lysosome and facilitates interactions with other proteins involved in lysosomal trafficking and autophagy. LAMP-1 participates in chaperone-mediated autophagy (CMA), which aids in the selective degradation of cytosolic proteins, and plays a key role in sorting lysosomal enzymes to appropriate destinations. Additionally, LAMP-1 is expressed on the surface of various immune cells, contributing to the regulation of immune responses and preventing self-damage during cytotoxic activities. Dysregulation or deficiency of LAMP-1 can lead to lysosomal storage disorders and may contribute to cancer progression and immune evasion.


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