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货号: TPFL0060
货期: 现货
价格: 1500;2480;3280
所属分类：
靶点: NF-κB p65
应用： WB, IHC-Autostainer, IF/ICC, FC , IP, ELISA, ChIP-qPCR
反应性 ： human, mouse, rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 65 kDa
MW(Observed)： 65 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
组成 ： PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 ： Protein A purification
储存 ： Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 ： 1000 ug/ml
克隆性 ： Recombinant
抗原&靶点信息
基因名称 ： NF-κB p65
蛋白名称 ： v-rel reticuloendotheliosis viral oncogene homolog A (avian)
别名 ： NF κB, p65, p65; RELA, RELA, NF Kappa B
背景：
Nuclear factor kB (NF-kB) is a sequence-specific DNA-binding protein complex which regulates the expression of viral genomes, including the human immunodeficiency virus, and a variety of cellular genes, particularly those involved in immune and inflammatory responses. The members of the NF-kB family in mammalian cells include the proto-oncogene c-Rel,p50/p105 (NFkB1), p65 (RelA), p52/p100 (NFkB2), and RelB. All of these proteins share a conserved 300-amino acid region known as the Rel homology domain which is responsible for DNA binding, dimerization, and nuclear translocation of NF-kB. The p65 subunit is a major component of NF-kB complexes and is responsible for trans-activation. NF-kB heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kB p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of IkB upon NF-kB the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kB complex. It associates with chromatin at the NF-kB promoter region via association with DDX1. This antibody is a rabbit monoclonal antibody raised against residues near the N terminus of human RELA.
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