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货号: TPFL0059
货期: 现货
价格: 980;1600
所属分类：
靶点: NLRP3
应用： WB, IF-Cell, IHC-P, FC
反应性 ： Human, Mouse, Rat
宿主物种 ： Rabbit
MW(CalcμLated) ： Predicted band size: 118 kDa
MW(Observed)： 118 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： unconjugated
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1,000-1:2,000 IF-Cell 1:100-1:500 IHC-P 1:400-1:5,000 FC 1:500-1:1,000
组成 ： 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
来源 ： Rabbit
纯化工艺 ： Protein A affinity purified.
储存 ： Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
克隆性 ： Monoclonal
克隆号 ： SC06-23
抗原&靶点信息
蛋白名称 ： NLRP3
别名 ： AGTAVPRL antibody; AII/AVP antibody; Angiotensin/vasopressin receptor AII/AVP like antibody; Angiotensin/vasopressin receptor AII/AVP-like antibody; C1orf7 antibody; Caterpiller protein 1.1 antibody; CIAS 1 antibody; CIAS1 antibody; CLR1.1 antibody; Cold autoinflammatory syndrome 1 antibody; 展开; AGTAVPRL antibody; AII/AVP antibody; Angiotensin/vasopressin receptor AII/AVP like antibody; Angiotensin/vasopressin receptor AII/AVP-like antibody; C1orf7 antibody; Caterpiller protein 1.1 antibody; CIAS 1 antibody; CIAS1 antibody; CLR1.1 antibody; Cold autoinflammatory syndrome 1 antibody; Cold autoinflammatory syndrome 1 protein antibody; Cryopyrin antibody; Familial cold autoinflammatory syndrome antibody; FCAS antibody; FCU antibody; LRR and PYD domains-containing protein 3 antibody; Muckle-Wells syndrome antibody; MWS antibody; NACHT antibody; NACHT LRR and PYD containing protein 3 antibody; NALP 3 antibody; NALP3 antibody; NALP3_HUMAN antibody; NLRP3 antibody; PYPAF 1 antibody; PYPAF1 antibody; PYRIN containing APAF1 like protein 1 antibody; PYRIN-containing APAF1-like protein 1 antibody; 折叠
数据库链接：
背景：
NLRP3 is expressed predominantly in macrophages and as a component of the inflammasome, detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NLRP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated with a number of organ specific autoimmune diseases. NLRP3 is a component of the innate immune system that functions as a pattern recognition receptor (PRR) that recognizes pathogen-associated molecular patterns (PAMPs). NLRP3 belongs to the NOD-like receptor (NLR) subfamily of PRRs and NLRP3 together with the adaptor ASC protein PYCARD forms a caspase-1 activating complex known as the NLRP3 inflammasome. NLRP3 in the absence of activating signal is kept in an inactive state complexed with HSP90 and SGT1 in the cytoplasm. NLRP3 inflammasome detects danger signals such as crystalline uric acid and extracellular ATP released by damaged cells. These signals release HSP90 and SGT1 from and recruit ASC protein and caspase-1 to the inflammasome complex. Caspase-1 within the activated NLRP3 inflammasome complex in turn activates the inflammatory cytokine, IL-1β. The NLRP3 inflammasome appears to be activated by changes in intracellular potassium caused by potassium efflux from mechanosensitive ion channels located in the cell membrane
细胞定位 ： Cytoplasm, Inflammasome, Secreted, Nucleus, Endoplasmic reticulum.
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