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货号: TPFL0058
货期: 现货
价格: 980;1600
所属分类：
靶点: Nrf2
应用： WB, IF-Cell, ChIP
反应性 ： Human, Mouse, Rat
宿主物种 ： Rabbit
MW(CalcμLated) ： Predicted band size: 68 kDa
MW(Observed)： 100 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： unconjugated
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:2,000 IF-Cell 1:100 ChIP Use 0.5~2 μg for 25 μg of chromatin.
组成 ： 1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
来源 ： Rabbit
纯化工艺 ： Protein A affinity purified.
储存 ： Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
克隆性 ： Monoclonal
克隆号 ： PSH11-20 反应性数据 Tested 已验证（内部验证通过） Published 文献已报道（未内部验证，但有文献支持） Predicted 预测可反应（基于高同源性） Not recommended 不推荐（内部验证未通过） Tested 已验证（内部验证通过） Published 文献已报道（未内部验证，但有文献支持） Predicted 预测可反应（基于高同源性） Not recommended 不推荐（内部验证未通过） WB IF-Cell ChIP Human Mouse Rat Mytilus Coruscus
抗原&靶点信息
蛋白名称 ： Nrf2
别名 ： erythroid derived 2 antibody; HEBP1 antibody; like 2 antibody; NF E2 related factor 2 antibody; NF-E2-related factor 2 antibody; NF2L2_HUMAN antibody; NFE2 related factor 2 antibody; NFE2-related factor 2 antibody; Nfe2l2 antibody; Nrf 2 antibody; 展开; erythroid derived 2 antibody; HEBP1 antibody; like 2 antibody; NF E2 related factor 2 antibody; NF-E2-related factor 2 antibody; NF2L2_HUMAN antibody; NFE2 related factor 2 antibody; NFE2-related factor 2 antibody; Nfe2l2 antibody; Nrf 2 antibody; NRF2 antibody; Nuclear factor (erythroid derived 2) like 2 antibody; Nuclear factor antibody; nuclear factor erythroid 2 like 2 antibody; Nuclear factor erythroid 2 related factor 2 antibody; Nuclear factor erythroid 2-related factor 2 antibody; Nuclear factor erythroid derived 2 like 2 antibody; 折叠
背景：
Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that may regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation, according to preliminary research. In vitro, NRF2 binds to antioxidant response elements (AREs) in the promoter regions of genes encoding cytoprotective proteins. NRF2 induces the expression of heme oxygenase 1 in vitro leading to an increase in phase II enzymes. NRF2 also inhibits the NLRP3 inflammasome. NRF2 appears to participate in a complex regulatory network and performs a pleiotropic role in the regulation of metabolism, inflammation, autophagy, proteostasis, mitochondrial physiology, and immune responses. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.
细胞定位 ： Cytoplasm, cytosol, Nucleus.
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