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货号: TPFL0055
货期: 现货
价格: 980;1600
所属分类：
靶点: Phospho-GSK3 beta (S9)
应用： WB, IF-Cell, IF-Tissue, IHC-P, FC
反应性 ： Human, Mouse, Rat
宿主物种 ： Rabbit
MW(CalcμLated) ： Predicted band size: 47 kDa
MW(Observed)： 47 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： unconjugated
隐藏域元素占位
详细信息
修饰-Modification ： Phosphorylation
推荐稀释比 ： WB 1:5,000-1:10,000 IF-Cell 1:100-1:500 IF-Tissue 1:50-1:200 IHC-P 1:50-1:200 FC 1:1,000
组成 ： 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
来源 ： Rabbit
纯化工艺 ： Protein A affinity purified.
储存 ： Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
克隆性 ： Monoclonal
克隆号 ： SY02-71
抗原&靶点信息
蛋白名称 ： Phospho-GSK3 beta (S9)
别名 ： Glycogen Synthase Kinase 3 Beta antibody; Glycogen synthase kinase-3 beta antibody; GSK 3 beta antibody; GSK-3 beta antibody; GSK3B antibody; GSK3B_HUMAN antibody; GSK3beta isoform antibody; Serine/threonine-protein kinase GSK3B antibody
背景：
Glycogen synthase kinase-3α (GSK-3α) and GSK-3β are highly similar isoforms of serine/ threonine kinases that regulate metabolic enzymes and transcription factors, which are responsible for coordinating processes such as glycogen synthesis and cell adhesion. GSK-3β activity is also required for nuclear activity of Rel dimers, which mediate an anti-apoptotic response to TNFα in mice. GSK-3 catalytic kinase activity is controlled through differential phosphorylation of serine/threonine residues, which have an inhibitory effect, and tyrosine residues, which have an activating effect. Growth factor stimulation of mammalian cells expressing GSK-3α and GSK-3β induces phosphorylation of Ser 21 and Ser 9, respectively, through a phosphatidylinositol 3-kinase (PI 3-K)-protein kinase B (PKB)-dependent pathway, thereby enhancing proliferative signals. Additionally, GSK-3 physically associates with cAMP-dependent protein kinase A (PKA), which phosphorylates Ser 21 of GSK-3α or Ser 9 of GSK-3β and inactivates both forms. GSK-3α/β is positively regulated by phosphorylation on Tyr 279 and Tyr 216, respectively. Activated GSK-3α/β participates in energy metabolism, neuronal cell development, and body pattern formation. Tyrosine dephosphorylation of GSK-3 is involved in its extracellular signal-dependent inactivation.
细胞定位 ： Cytoplasm, Nucleus, Cell membrane.
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