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货号: TPFL0042
货期: 现货
价格: 1790;3500;6900
所属分类:
靶点: RUNX2
应用: IHC-P, IF/ICC, ELISA
反应性 : Human, Mouse
宿主物种 : Rabbit
MW(CalcμLated) : 57kDa
MW(Observed): Refer to figures
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : IHC-P 1:500 - 1:1000 IF/ICC 1:200 - 1:500 ELISA Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
组成 : Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
纯化工艺 : Affinity purification
储存 : Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS containing 50% glycerol and 0.05% BSA
克隆性 : Monoclonal
克隆号 : ARC3265
抗原&靶点信息
基因名称 : RUNX2
蛋白名称 : Runt-related transcription factor 2
别名 : CCD; AML3; CCD1; CLCD; OSF2; CBFA1; OSF-2; PEA2aA; PEBP2aA; CBF-alpha-1; RUNX2
背景:
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.


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