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Vimentin Antibody (Rabbit mAb) [B13H12]

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说明书下载
货号: TPFL0037
货期: 现货
价格: 790;1240;1990;3790
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所属分类:


靶点: VIM
应用: WB, IHC, IF, FCM
反应性 : Human, Mouse, Rat, Hamster, Monkey
宿主物种 : Rabbit
MW(CalcμLated) : 53 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:1000
组成 : PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN₃
储存 : –20°C (avoid freeze-thaw cycles), 2 years
克隆性 : Monoclonal
克隆号 : B13H12

抗原&靶点信息

特异性 : Vimentin Antibody (Rabbit mAb) [B13H12]
基因名称 : VIM
蛋白名称 : Vimentin
别名 : epididymis secretory sperm binding protein | FLJ36605 | VIM | VIME | Vimentin

数据库链接:

Organism

基因 ID

SwissProt

背景:

The cytoskeleton contains three types of cytoplasmic fibers—microfilaments (also known as actin filaments), intermediate filaments, and microtubules. Different types of intermediate filaments are characterized by their expression in specific cell types: cytokeratins in epithelial cells, glial fibrillary acidic protein (GFAP) in glial cells, desmin in skeletal, visceral, and certain vascular smooth muscle cells, vimentin in cells of mesenchymal origin, and neurofilaments in neurons. GFAP and vimentin together form intermediate filaments within astrocytes, influencing their movement and morphology. Vimentin undergoes structural modifications and reorganization in response to external signals, helping to coordinate various signaling pathways. During mitosis, vimentin is phosphorylated at Ser56 by CDK1. Phosphorylation of vimentin at Ser56 in smooth muscle cells plays a role in regulating the arrangement of vimentin filaments in response to serotonin. Reorganization of vimentin and other intermediate filaments is essential for lymphocyte adhesion and migration through endothelial cells.

细胞定位 : Cell membrane, cytoplasm, cytoskeleton, intermediate filament, inner membrane, nucleus

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