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Anti-CD4Antibody

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说明书下载
货号: TPFL0028
货期: 现货
价格: 1717.6
+

所属分类:


靶点: CD4
应用: WB, IHC-P, IHC-Fr, IP
反应性 : Mouse
宿主物种 : Rabbit
MW(CalcμLated) : 51 kDa
MW(Observed): 51 kDa
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : IP: 1/40;WB: 1/1000;IHC-Fr: 1/200;IHC-P: 1/1000
组成 : pH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
纯化工艺 : Affinity purification Protein A
储存 : Form: Liquid,Shipping condition: Blue Ice,Short-term storage (1–2 weeks): +4°C,Long-term storage: -20°C,Aliquot information:,Aliquot upon delivery,Storage note: Avoid freeze-thaw cycles.
克隆性 : Monoclonal
克隆号 : EPR19514

抗原&靶点信息

基因名称 : Cd4
蛋白名称 : T-cell surface glycoprotein CD4
别名 : CD4, T-cell surface glycoprotein CD4, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, Cd4

数据库链接:

Organism

基因 ID

SwissProt

背景:

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule : peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.

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