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货号: TPFL0025
货期: 现货
价格: 3688.32
所属分类：
靶点: ErbB2
应用： Flow Cyt (Intra), IHC-P, I-ELISA, WB, IP, ICC/IF
反应性 ： Mouse, Rat, Human
宿主物种 ： Rabbit
MW(CalcμLated) ： 137 kDa
MW(Observed)： 180 kDa; 15 kDa; 36 kDa; 90 kDa; 80 kDa
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： IP: 1/30；WB: 1/1000；ICC/IF: 1/250；Flow Cyt (Intra): 1/60；IHC-P: 1/4000
组成 ： pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
纯化工艺 ： Affinity purification Protein A
储存 ： Form: Liquid，Shipping condition: Blue Ice，Short-term storage (1–2 weeks): +4°C，Long-term storage: -20°C，Aliquot information:，Aliquot upon delivery，Storage note: Avoid freeze-thaw cycles.
克隆性 ： Monoclonal
克隆号 ： EPR19547-12
抗原&靶点信息
特异性 ： <p>Only reacts with weakly in mouse 4T1 cells.<br>This antibody could recognize ErbB2 and weak cross reaction with ErbB4&#46;&amp;nbsp;<br>Mouse and rat species are recommended based on WB results, we do not guarantee IHC-P for mouse and rat.</p>
基因名称 ： ERBB2
蛋白名称 ： Receptor tyrosine-protein kinase erbB-2
别名 ： CD340, HER2, MLN19, NEU, NGL, ERBB2, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, MLN 19
背景：
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
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