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货号: TPFL0016
货期: 现货
价格: 4038.62
所属分类：
靶点: p75
应用： WB, Flow Cyt (Intra), ICC/IF, IP, IHC-P
反应性 ： Mouse, Rat, Human
宿主物种 ： Rabbit
MW(CalcμLated) ： 45 kDa
MW(Observed)： 75 kDa
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： IP: 1/50；WB: 1/1000 - 1/10000；ICC/IF: 1/50；Flow Cyt (Intra): 1/60
组成 ： pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA
纯化工艺 ： Affinity purification Protein A
储存 ： Form: Liquid，Shipping condition: Blue Ice，Short-term storage (1–2 weeks): +4°C，Long-term storage: -20°C，Aliquot information:，Aliquot upon delivery，Storage note: Avoid freeze-thaw cycles.
克隆性 ： Monoclonal
克隆号 ： EP1039Y
抗原&靶点信息
基因名称 ： NGFR
蛋白名称 ： Tumor necrosis factor receptor superfamily member 16
别名 ： CD271, TNFRSF16, NGFR, Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, Low-affinity nerve growth factor receptor p75NGFR, Low-affinity nerve growth factor receptor p75NGR, p75 ICD, NGF receptor
背景：
Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed : 24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed : 26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed : 23785138). Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed : 22566094).
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