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货号: STA00673
货期: 次日发货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: BTK
应用: WB IP
反应性 : Human
宿主物种 : Rabbit
MW(Observed): 76kDa
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500~1:1000 IP1:20
纯化工艺 : Affinity-chromatography
储存 : Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
克隆性 : Monoclonal
抗原&靶点信息
特异性 : BTK Antibody detects endogenous levels of BTK
别名 : AGMX1; Tyrosine-protein kinase BTK; BTK; Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase; ATK; BPK;
数据库链接:
背景:
Btk plays an important role in B lymphocyte development, differentiation and signaling. Activation of B cells by various ligands is accompanied by Btk membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane-localized Btk is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223.


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