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STK3 Antibody

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说明书下载
货号: STA00564
货期: 次日发货
价格: 50μL/960;100μL/1600;200μL/2560
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所属分类:


靶点: STK3
应用: WB IHC ICC/IF IP FC
反应性 : Human Mouse Rat
宿主物种 : Rabbit
MW(Observed): 56kDa
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB: 1:1000~1:5000 IHC: 1:50~1:100 ICC/IF: 1:50~1:100 IP: 1:50 FC: 1:50
纯化工艺 : Affinity-chromatography
储存 : Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
克隆性 : Monoclonal

抗原&靶点信息

特异性 : STK3 Antibody detects endogenous levels of STK3
别名 : STK3; Mess1; MST-2; MST2; Serine/threonine kinase 3; KRS1; STE20-like kinase MST2;

数据库链接:

Organism

基因 ID

SwissProt

背景:

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

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