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货号: STA00480
货期: 次日发货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: HIF-1
应用: WB IHC
反应性 : Human
宿主物种 : Rabbit
MW(Observed): 87kDa
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500~1:2000 IHC 1:500~1:2000
纯化工艺 : Affinity-chromatography
储存 : Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
克隆性 : Monoclonal
抗原&靶点信息
特异性 : HIF-1 beta Antibody detects endogenous levels of total HIF-1 beta
别名 : ARNT;HIF-1beta;HIF1B;HIF1BETA;TANGO;bHLHe2;
数据库链接:
背景:
HIF-1β is also known as AhR nuclear translocator (ARNT) due to its ability to partner with the aryl hydrocarbon receptor (AhR) to form a heterodimeric transcription factor complex. Together with AhR, HIF-1β plays an important role in xenobiotics metabolism. In addition, a chromosomal translocation leading to a TEL-ARNT fusion protein is associated with acute myeloblastic leukemia. Studies also found that ARNT/HIF-1β expression levels decrease significantly in pancreatic islets from patients with type 2 diabetes, suggesting that HIF-1β plays an important role in pancreatic β-cell function.


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